Enantioselective Hydrogenation of Ethyl Pyruvate Catalyzed by 1,2-Diphenyl-ethylenediamine-Modified Iridium Complex: Effect of Solvent
نویسندگان
چکیده
منابع مشابه
Highly enantioselective iridium-catalyzed hydrogenation of heteroaromatic compounds, quinolines.
The highly enantioselective hydrogenation of quinoline derivatives is developed using [Ir(COD)Cl]2/(R)-MeO-Biphep/I2 system, and this methodology has been applied to the asymmetric synthesis of three naturally occurring alkaloids angustureine, galipinine, and cuspareine. This method provided an efficient access to a variety of optically active tetrahydroquinolines with up to 96% ee.
متن کاملEnantioselective iridium-catalyzed hydrogenation of 3,4-disubstituted isoquinolines.
The past decade has witnessed rapid progress in the field of asymmetric hydrogenation of aromatic compounds, a transformation, which is regarded as one of the most straightforward means for accessing enantiopure cyclic compounds. Extensive research has significantly expanded the substrate scope of this reaction, and substrates such as quinolines, quinoxalines, indoles, furans, pyrroles, pyridin...
متن کاملHighly Enantioselective Iridium‐Catalyzed Hydrogenation of Cyclic Enamides
The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H2 pressure to 3 bar resulted in an ...
متن کاملEnantioselective synthesis of alcohols and amines by iridium-catalyzed hydrogenation, transfer hydrogenation, and related processes.
The preparation of chiral alcohols and amines by using iridium catalysis is reviewed. The methods presented include the reduction of ketones or imines by using hydrogen (hydrogenations), isopropanol, formic acid, or formate (transfer hydrogenations). Also dynamic and oxidative kinetic resolutions leading to chiral alcohols and amines are included. Selected literature reports from early contribu...
متن کاملHighly enantioselective hydrogenation of 2,4-diaryl-1,5-benzodiazepines catalyzed by dendritic phosphinooxazoline iridium complexes.
A PHOX with arms: A series of dendrimers with Ir phosphinooxazoline (PHOX) cores were designed and synthesized and found to be highly effective and recoverable catalysts for asymmetric hydrogenation of 2,4-diaryl-1,5-benzodiazepines. An obvious positive dendritic effect on reactivity was observed, leading to chiral nitrogen-containing heterocycles with excellent enantioselectivities.
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2014
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2014.15372